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Grant Proposal Presentation

Transcript: Salad for Sight: Grant Proposal We are dedicated to combating childhood blindness due to vitamin A deficiency through providing nutrients necessary to the foundation of a balanced diet. Our goal is to aid residents of rural Cambodia in their journey to an improved life. Financial Projections Viability Schedule Construct hydroponic lettuce gardens Lettuce has the 5th highest concentration of vitamin A Easiest to produce Soil unfit for traditional methods Work with organizations in rural Cambodia to provide communities with supplies and manuals to treat vitamin A deficiency Hydroponic lettuce gardens can be grown using simple techniques and materials that are available worldwide We created an instruction manual, with images, and had it translated into Khmer We successfully grew our own hydroponic lettuce to test the recommended methods The Partners If we receive the grant money: November 2013: U.S. supplies will be ordered and shipped. Cambodia supplies purchased. December 2013: Gardens will be planted. Lettuce will began growing in cool, winter months. January 2014: First harvest of lettuce. Lettuce will begin to regrow for next harvest. 2014 - 2016: Continue supplying with funds for lettuce production. Future: Lettuce production sustained from profits of selling excess. Sustainable Cambodia Works directly with villages throughout Cambodia to better the community’s health care, food supply, clean water, education, and economy Helen Keller International Has numerous projects throughout Cambodia that integrate food sources high in vitamin A to the local diet photo credit Nasa / Goddard Space Flight Center / Reto Stöckli Province of Kampong Chhnang in rural Cambodia Targeted this area due to its very high vitamin A deficiency prevalence rate River in the middle of province supplies water Contacts established in region Questions? The Community 228 million people living with treatable visual impairment Can not reach full potential Vitamin A Deficiency causes 70% of childhood blindness (World Health Organization) 23% of children in Cambodia have vitamin A deficiency Easily treatable with proper nutrition The Problem Sustainability Build fewer gardens Continual supplies for several years When lettuce production reaches its maximum, gardeners may sell or trade their lettuce Lettuce plants produce seeds for next grow cycle Grow bottles are recycled and would be reused Funds only needed for initial construction Cuts down on plastic pollution The Solution Cost per Grow Bottle: $0.72 Cost of Grow Media per Year: $0.72 Shipping: $300 Number of Grow Bottles: 325 Years: 2014 - 2016 Total: $1002 Megan Chang-Haines and Zoë Siddall

Grant Proposal Presentation

Transcript: Sensory Processing Disorders and ASD The rate of ASD has increased from 1:150 in 2000 t0 1:68 in 2010 ("Autism Spectrum Disorder (ASD)," n.d.) The DSM-V changed the criteria for diagnosing Autism. One criterion for the diagnosis of ASD is restrictive or repetitive behavior, interests, or activities. For example, hyperreactivity or hyporeactivity to sensory input (American Psychiatric Association, 2013). The Effects of Multi-Sensory Environments on Students with Autism Spectrum Disorder Agenda Sensory processing disorders and ASD Sensory Modulation Disorders (SMDs) Sensory integration theory and multi-sensory environments Positive effects of multi-sensory environments Grant proposal Purpose: to determine whether or not multi-sensory environments effect motor skills in individuals with ASD. Participants: Thirty-four children (40-65 months) diagnosed with ASD participated. Methods: Every participant received sensory integration therapy in a multi-sensory environment (ex: swings, balancing boards, trampolines, see saws, bubbles, finger paints, stress balls, weighted blankets). Pre- and post- tests (Peabody Developmental Motor Scale) were done to assess both gross and fine motor skills and the effectiveness of sensory integration therapy on motor skill levels. Pre- and post- assessment scores were then compared. Results: After comparing pre- and post- treatment mean scores, gross and fine motor skills significantly improved. (Karim & Mohammed, 2015) Work Cited Autism Spectrum Disorder (ASD). (n.d.). Retrieved from Centers for Disease Control and Prevention Website: http://www.cdc.gov/ncbddd/autism/data.html American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing. Ben-Sasson, A., Hen, L., Fluss, R., Cermak, S. A., Engel-Yeger, B., & Gal, E. (2009). A meta-analaysis of sensory modulation symptoms in individuals with autism spectrum disorders. Journal of Autism And Developmental Disorders, 39(1), 1-11. Green, S. A., Ben-Sasson, A., Soto, T.W., & Carter, A. S. (2012). Anxiety and sensory over-responsivity in toddlers with autism spectrum disorders: bidirectional effects across Ttme. Journal of Autism And Developmental Disorders, 42(6), 1112-1119. Hill, L., Trusler, K., Furniss, F., & Lancioni, G. (2012). Effects of multisensory environments on stereotyped behaviours assessed as maintained by automatic reinforcement. Journal of Applied Research in Intellectual Disabilities, 25(6), 509-521 Hochhauser, M., & Engel-Yeger, B. (2010). Sensory processing abilities and their relation to participation in leisure activities among children with high-functioning autism spectrum disorder (HFASD). Research in Auis Spectrum Disorders, 4(4), 746-754. Interdisciplinary Council on Developmental and Learning Disorders (ICDL-DMIC) Work Groups. (2005). Interdisciplinary Council on Developmental and Leaning Disorders Diagnositic manual for infancy and early chldood mental health disorders, developmental disorders, regulatory-sensory processing disorders, language disorders, and learning challenges. Bethesda, MD: Author. Karim, A. E. A., & Mohammed, A. H. (2015). Effectiveness of sensory integration program in motor skill in children with autism. Egyptian Journal of Medical Human Genetics, 16(4), 375-380. May-Benson, T. A., & Kommar, J. A. (2010). Systematic review of the research evidence examining the effectiveness of interventions using a sensory integrative approach for children. American Journal of Occupational Theapy, 64(3), 403-414. Miller, L. J., Anzalone,, M. E., Lane, S., Cermak, S. A., & Osten, E. (2007). Concept evolution in sensory integration: A proposed nosology for diagnosis. American Journal of Occupational Therapy, 61(2), 135-140. Pfeiffer, B. A., Koenig, K., Kinnealey, M., Sheppard, M., & Henderson, L. (2011). Effectiveness of sensory integratin inteventions in children with autism spectrum disorders: A pilot study. American Journal of Occupational Therapy, 65(1), 76-85. Smith, R., & Sharp, J. (2013). Fascination and isolation: a grounded theory exploration of unusual sensory experiences i adlts with asperger syndrome. Journal of Autism & Developmental Disorders, 43(4), 891-910. doi:10.1007/s10803-012-1633-6 Thompson, C. J. (2011). Multi-sensory intervention observational research. International Journal of Special Education, 26(1), 202-214. Zimmer, M., Desch, L., Rosen, L. D., Bailey, M. L., Becker, D., Culbert, T.P., & Adams, R. C. (2012). Sensory integration therapies for children with developmental and behaviral dsorders. Pediatrics, 129(6), 1186-1189. Multi-Sensory Environments Sensory integration theory usually takes place in multi-sensory environments. These gyms have equipment such as swings, exercise balls, trapeze bars, ramps, balance beams, rope pulls, and balance boards. They may also contain equipment such as, brushes, fiber optic string lights, and LED lights. Purpose: to study the effects of multi-sensory

Grant Proposal Presentation

Transcript: Sclerites cover its foot form armor-like shield ~8mm long Biomineralization: composed of pyrite (FeS2) & greigite (Fe3S4) (Waren et al. 2003) Biomineralization: an organism incorporates inorganic materials in its structures. (Allaby et al. 2013) What has been previously suggested: since the iron sulfide is pure within the conchiolin (protein that makes outer shell) and forms an armor-like structure: the gastropod controls minerlization of iron sulfide into sclerites (Waren et al. 2003). Isotopic data from iron and sulfur samples concludes mineralization occured as a result of hydrothermal fluid, not bacterial symbionts (Suzuki et al. 2006) BUT..... Bacteria found where sclerites overlap (Waren et al. 2001)) Greigite, a component of the sclerite is sometimes produced by magnetotatic bacteria (Lefèvre & Bazylinski 2013). Perhaps a symbiotic relationship between Crysomallon r. and an episymbiotic (lives on and within host) bacteria that is capable of oxidizing hydrothermal fluids into iron sulfides... Experimental design.... Interpretation / Analysis If the gastropod without episymbionts displays sclerite growth, this supports the hypothesis that the gastropod is responsible for biomineralization Control and Experimental Groups Background The bacteria found in the gastropod are responsible for the mineralization of the iron sulfide and act in a symbiotic relationship with the gastropod. As proposed in previous theories, the gastropod may facilitate the bacterial mineralization to form the intricate sclerites, but the symbiotic bacteria undergo the actual chemical reactions responsible for the iron sulfide sclerites. 1: Attain C. Squeriferum and Taxonomically identify M. Allaby (2013). A dictionary of geology and earth sciences (4 ed.). Oxford Universtiy Press. C. L. Van Dover, et al. (2001). Biogeography and Ecological Setting of Indian Ocean Hydrothermal Vents. Science 294(5543): 818-823. R.M. Gallant, K.L. Damm (2006). Geochemical controls on hydrothermal fluids from Kairei and Edmond Vent Fields, 23° - 25°S, Central Indian Ridge. G3 Geochemistry, Geophysics, Geosystems 7(6) C.T. Lefèvre, D.A. Bazylinski (2013). Ecology, Diversity, and Evolution of Magnetotactic Bacteria. Microbiol Mol Biol Rev 77(3): 497-526. S. Nakagawa, S. et al. (2013). Allying with armored snails: the complete genome of gammaproteobacterial endosymbiont. The ISME Journal 2014(8):40-51. Y. Suzuki et al. (2006). Sclerite formation in the hydrothermal-vent “scaly-foot” gastropod---possible control of iron sulfide biomineralization by the animal. Elsevier 242(1-2): 39-50. A. Waren, S Bengston, S.K. Godffredi, C.L. Van Dover (2003). A hot vent gastropod with iron sulfide dermal sclerites. Science 302(5647): 1007 Grant Proposal Presentation 3 Groups Control Gastropod with bacteria Gastropod without episymbiotic bacteria Cultured episymbiotic bacteria Groups exposed to both sea-water and hydrothermal vent fluid environments 2: Containment 3. Measurement of Sclerites If neither experimental groups produce results, then the study supports the hypothesis that together the bacteria and gastropod are responsible for sclerite synthesis and biomineralization Crysomallon squamiferum Hypothesis: Van Dover et al. 2001) Motivation: Biomineralization If the episymbiotic bacteria are able to produce iron sulfide, then this supports the hypothesis that they are responsible for biomineralization Nickname:"the scaly-footed gastropod" Habitat: Kairei deep-sea hydrothermal vents of the Indian Ocean Environment 1: Sea-water with energy resources (Nakagawa et al. 2013) Environment 2: Simulated Hydrothermal Vent Fluid (Gallant & Damm 2006) If the control gastropod sclerites grow, the experiment is effective in simulating hydrothermal vent environment Measure sclerites in order to assess biomineralization during the experiment Bibliography

Grant Proposal Presentation

Transcript: Our team's experience and expertise enable us to create sturdy, sustainable bridges in developing regions. Addresses the underlying issue, which is the lack of accessibility to basic services, amenities, and trading markets. This bridge will provide this accessibility for the people of Dari by connecting them to the nearby town of Omereque. This will stimulate economic activity in the local area as 6000 more people will be introduced to the local markets. Bridge Opening Ceremony Emma Plum Increased secondary education enrollment and attendance Promote gender equality and empowerment of women Increased income and trade Increased healthcare accessibility Bridge Length: 120 m Spans: Rio Mizque Function: provides approximately 6000 people with access to education, healthcare, and trading markets Duration: 20 weeks Requested Funds: $71, 000.00 - Sand, gravel, and timber collected and processed locally - Other necessary materials purchased in the nearby city Santa Cruz de la Sierra Survey BUDGET -Construction does not require heavy machinery, but can be completed entirely by human effort -structure requires very little maintenance University of Toronto - Bolivian workers will be paid approximately twice the Bolivian minimum wage plus extra depending on skill level of their work 1 km from school, attendance likelihood decreases 1.3% Illness leads to cycle of dependance and poverty Indigenous rural students 47.5% less likely to complete secondary school Why build a bridge? Consequences 24% Sabrina Peacock Princeton University Scope Progress Thus Far Why is this the best approach? Evidence - Total budget with contingency is $88, 247.52 - We are asking for a contribution of 80% of the budget *Expected Traffic: 300 people per day* Increased per capita income in two years Secondary school attendance and enrollment Specialized farming increases Increase in number of visits to healthcare facilities Increase in number of retail businesses Increase in employment for women Political Scientist and Humanitarian Maintenance training for Bridge Committee along the way Erinn Scarlett Weeks 5-17 Our Team Former NGO Director Intern Sustainable Current Implementation In comparison to other possible solutions of building a school or health clinic within the village, this solution is much more feasible. The total budget for this project is $88, 247.52 while it would cost well over $100 000 to build a school or hospital Partners in Bolivia Zac Mustard - Local government has agreed to finance 20% of the budget plus the transport of materials Material Collection Local community 12% Reduced school attendance Limited access to healthcare and markets Reliance on family and neighbor support Limited employment opportunities 10-20% Effective University of Waterloo Aalok Green Contingency non-governmental organization We have planned several ways for external individuals to evaluate our progress and measure our results. Some of these methods include: Timely Progress Reports (Every 5 weeks) Measuring Bridge Traffic Analyzing School Attendance Records Analyzing changes in revenue through municipality records. Conducting a local survey of the villagers' opinions of their local bridge. Expected Outcomes Building permits approved, willingness to co-operate Government support in place 18% a group of professionals with a wide range of applicable knowledge and skills The Dari Project Evaluation and Progress Reports Description of Community Problem Implementation Budget Evaluation Bridge Over Troubled Water Organization Isolation University of Ottawa Architect Construction The bridge we create will give locals access to the city for at least 30 years. Rachel White Dari, Bolivia Omereque municipality, Narciso Campero Province AGENDA McMaster University Bridge committee Rain season inhibits crossing River remains high in dry season Nearest crossing: two hour walk across steep hillsides Engineering 15% Rio Mizque River located on steep hillside isolated rural community several neighbouring communities total population : ~ 6,000 indigenous population Stanford University Bridge Over Troubled Water Organization - Actual building of the bridge will be done in most part by local volunteers Week 18 formed in 2003, have built four bridges since through our projects in Latin America Issue Engineer 8-16% Weeks 1-4 Feasible Lawyer Nearby businesses supplying material Weeks 19-20 Local workers Description of the Community

Grant Proposal Presentation

Transcript: Background Gram-negative spiral-shaped bacterial pathogen Damages stomach tissue and causes peptic ulcers Utilizes urease for colonization of gastric mucosa H. pylori present in 50-75% of world's population Atherosclerosis Plaque buildup within arteries of the heart Symptoms can differ based on affected artery Shortness of breath and chest pain are common Major cause of coronary artery disease 1) Transcriptomics to analyze differences between strains of H. pylori isolated from patients with atherosclerosis Control groups Patient age range Ideal result? Initial Research H pylori triggers inflammatory state within individual This can contribute to the onset of atherosclerosis Certain species of bacteria present within plaque itself 2) Proteomics to measure amounts of urease in individual's blood samples Why? Ideal result? 3) qRT-PCR to measure levels of gene expression from pro-inflammatory cytokine genes Why? Caveat? How to address this? Societal Impact + Importance H. pylori has potential to lead to gastric cancer Cardiovascular disease is the leading cause of death worldwide Promotion of heart health as well as emphasis on stroke and heart-attack prevention Proposed Experiments Onset of Atherosclerosis by Helicobacter pylori Anya Agarwal BIOL 384 - 001: Microbial Pathogenesis of Infectious Disease Dr. Ritzert 17th December 2023 Photo Links: https://badgut.org/wp-content/uploads/Image-Content-hpylori-1.png https://www.pennmedicine.org/-/media/images/medical%20and%20research%20images/microscopic%20images/coronary_heart_disease_graphic_1.ashx https://content.healthwise.net/resources/13.9/en-us/media/medical/hw/h9991459_001.jpg https://cdn.labmanager.com/assets/articleNo/31078/aImg/55572/lm-oct23-images1000x50011-s.jpg https://www.silantes.com/wp-content/uploads/2023/10/proteomics-overview.jpg https://www.researchgate.net/publication/324595400/figure/fig16/AS:616979568267264@1524110800198/Quantitative-RT-PCR-qRT-PCR-results-for-the-differentially-expressed-transcripts-in.png https://i0.wp.com/yourhealthforumbydrcirino.org/wp-content/uploads/2021/05/H.-pylori.jpg?resize=598%2C1024&ssl=1 https://www.verywellhealth.com/thmb/MT8bVVf0uHljl_9juoNxjZBISeg=/1500x0/filters:no_upscale():max_bytes(150000):strip_icc()/overview-of-heart-disease-4160961_final-152f46073f2242999b771e409973825b.png

GRANT PROPOSAL PRESENTATION

Transcript: GRANT PROPOSAL PRESENTATION 11-7-2013 About Us What do we do? Thank you Goal through this partnership - Increase relations - Employee volunteer opportunities - Increase our visibility through corporate partnership - Branding on promotional material - Include as event sponsor - Fundraising events Our Partnership Mission As a faith-based organization, it is the mission of Midwest Food Bank to alleviate hunger and poverty by gathering and distributing food donations to not-for-profits and disaster sites without cost to the recipients. INDIANAPOLIS DIVISION - Committed to serve those in need in Indiana - Spread across 43 counties - Provide food to 60,000 individuals - Partnered with Indy Hunger network and Promise for protein. - Indy Hunger network- Its network is a coalition of representatives from leading anti-hunger organizations, both public and private, in Indianapolis. Promise for Protein- over 40,000 pounds of ground pork will be donated to the Midwest Food Bank this year. The pork is then distributed to over 40 counties and 220 food banks in Indiana. - Salvation Army - Midwest Food bank, a faith based organization came into existence in 2003 when Keiser family served food in their family farm. - The Indianapolis Division was established in 2009. - Partner with local non-profits who help with food requirements without a cost to the recipients. - Provide 500 organizations across the Midwest. The food given out each month now reaches over 100,000 people. - We are present in Bloomington, IL , Peoria, IL , Indianapolis, IN , Peachtree, Georgia - Distribute food upto $1 Million. - Disaster relief - Need grant of $250,000 for operational cost. - 2013 Budgeted cash operating costs- $420, 000 - $15 Million 2013 estimated amount of food distributed - Would like to increase our reach and eliminate hunger as best as we could. - Some of the cost would be used for: - Buying a tractor - change the roof, - buy storage material, - Increase the size of the facility, - buy extra land for expanding the garden of hope. -Invest in perishable food. -Pick up trucks

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